Introduction: – Thrombocytopenia (platelet count<1.5lakhs/µL) is one of the most common hematological problems in NICUs, with 18–35% of the neonates developing this problem. More common among ELBW (< or = 1000 grams birth wt.) or Preterm babies (GA < or = 32–36 weeks) or Sick neonates. In contrast, only 2% of neonates are thrombocytopenic at birth with Severe Thrombocytopenia (platelet count<50,000/µL) in less than 3/1000 term infants. Aims and Objectives: – To determine the etiological correlation to neonatal thrombocytopenia. Material and Methods: – 70 neonates, having platelet count (<1.5 lakh/ µL), were selected from NOVEMBER 2017 to SEPTEMBER 2019 among those admitted to NICU. Initial platelet count is done on admission and counts repeated after any therapeutic intervention. Observation and Results: – Severe thrombocytopenia (<50,000/µL) is present in 44.3%. Of the thrombocytopenic neonates (n=70), 64.3% were preterm, 78.6% were LBW, 72.8% had Septicemia, 40% had Birth asphyxia, 17.1% MAS, 18.5% had DIC and 42.8% had NEC. 55.7% presented early (<72 hrs.) and 44.3% presented Late (>72hrs). Conclusion: – Significant association is observed with Maternal PIH, NEC, LBW, Sepsis and prematurity. Factors leading to Sepsis directly influence platelet counts.