Introduction: Lymphadenopathy is a common problem in children and evaluation of child with lymphadenopathy is a common clinical scenario for the paediatrician, lymphadenopathy in children may be due to systemic infections mostly systemic viral infections. Objective of this study is clinicopathological profile of significant cervical lymphadenopathy among the children attended to department of paediatrics ASARAM hospital,Eluru,AP. Material and methods: This was a prospective study done on 50 children with significant lymphadenopathy attended to Dept of Paediatrics, ASRAM, Eluru during the period of Augst 2017 to August 2019. Results: 74.4% of significant lymphadenopathy is due to Reactive hyperplasia followed by 15% due to Tuberculosis, and 6.9% due to suppurative conditions. Conclusions: Non diagnostic hyperplasia due to Reactive lymphadenitis commonest cause of significant cervical lymphadenopathy in children. infections are commonest etiology for significant lymphadenopathy.