IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-9-2-24141 Original Research Paper A STUDY ON NEURODEVELOPMENTAL OUTCOME IN INFANTS WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY Chaitanya Arsi Dr. February 2020 9 2 01 02 ABSTRACT

BACKGROUND: To assess the neurodevelopmental outcome in term neonates with Hypoxic ischemic encephalopathy up to one year of age.To assess the relationship between severity of Hypoxic Ischemic Encephalopathy and neurodevelopmental outcome. To assess the neurodevelopmental outcome by DASII (Development Assessment Scale for Indian Infants) at the age of 1 year. PATIENTS AND METHODS: This study was conducted in a tertiary care hospital, ASRAM,Eluru.It is a hospital based prospective analytical study conducted on 150 term neonates with HIE admitted in NICU from September 2017 to September 2019. Follow up of these infants done in OPD at 3 ,6,9,12 months. Tone assessment done by Amiel Tison angles.At each visitanthropometricmeasurements,developmental milestones were noted.Neurodevelopmentaloutcomel assessed by DASII at the age of one year. RESULTS:Incidence of abnormal neurodevelopmental outcome was 22.6%, tone abnormality 20.6%, Seizures 22%, moderate sensorineural hearing loss 1.4%, vision abnormalities 2 % in HIE infants. There was a significant statistical correlation between the decrease in head circumference and severity of HIE during 6th, 9th, 12th month follow up visit (p 0.001).There was significant statistical association between tone abnormality and severity of HIE during follow up. CONCLUSION: Head circumference and tone abnormality helps to predict developmental outcome on follow up. Early detection of abnormal neurodevelopment so that early intervention could be initiated to decrease the morbidity in infants with Hypoxic ischemic encephalopathy.