The study aims to evaluate efficacy of drugs with jaw opening exercises in OSMF patients and comparing the same with addition of therapeutic ultrasound in stage II and stage III OSMF patients. 60 clinically diagnosed patients of OSMF were included having mouth opening 26mm–35mm (stage II) and 15mm–20mm (stage III) . Individual case history was recorded with details of habits and symptoms. Patients were divided into two groups of 30 patients each with institution of conventional method of treatment in Group I and ultrasound therapy in addition to conventional therapy in Group II.OSMF affects patients having positive history of betel nut chewing,young age and is more common in males. Significant relief in clinical symptoms and increased mouth opening during the course of treatment and quick relief was observed in Gr. II as compared to Gr. I patients treated by conservative therapy alone. Thus, Therapeutic Ultrasound’ is a non–invasive treatment modality with no reported side effects and showing promising results making it sufficient to be used alone or along with conservative therapy as an alternative in the management of OSMF.