Introduction: Thyroid nodules are common. A solitary nodule may become cosmetically distressing to a patient and commonly cause pressure symptoms. However, the major concern relates to the potential risk of malignancy. Objectives: To determine the prevalence of solitary nodule thyroid and the incidence of solitary nodule thyroid turning out to be malignant. Materials and Methods: This is a prospective study done in patients with clinically palpable solitary nodule thyroid at Pinnamaneni Siddhartha Institute of Medical Sciences Gannavaram. Total duration of the study is two years, from 2017 August to 2019 July. Results: Among a total of 121 thyroid cases, solitary nodule thyroid is found in 78 cases (64%). Majority were females 82%. Benign lesion is the most common lesion in both males and females. Maximum % of the cases i.e. 35% of the cases belonged to the age group 31–40 years. Follicular adenoma is the most common histopathological finding in 48.7% of the cases. The incidence of malignancy is 12.8%. Hemi–thyroidectomy is the most common method used in 89% cases. Conclusion: Solitary nodule thyroid is most common in 3rd–5th decades. Females are most commonly affected than males.12.8% of solitary thyroid nodules are malignant. Suspect malignancy at extremes of age.