Background: Dentistry is a high– risk profession in terms of muscle and skeletal disorders. The study aims to prove the effect of Thoracic Mobilization versus Thoracic Manipulation in chronic mechanical neck pain in dentists. Materials and Methods:30 participants of age group 22–30 years were selected. They were randomly allocated into two groups: Group I was given Thoracic Mobilization and Group II was given Thoracic Manipulation, 15 in each group. Thoracic Mobilization and Manipulation were performed for 4 weeks, 2 sessions/week. Postural correction exercises were also advised to both the groups. Cervical Flexion Range of Motion(CFROM), Visual Analog Scale(VAS) and Neck Disability Index(NDI) were assessed before and after 4 weeks of intervention. Result: In group I, the pre and post intervention mean, SD of cervical flexion range of motion were 32.53 + 2.44 and 39.20 + 1.65 respectively. The pre and post intervention mean, SD of visual analog scale were 5.93 + 1.38 and 1.80 + 0.77 respectively. The pre and post intervention mean, SD of neck disability index were 16.31 + 5.41 and 5.05 + 2.34 respectively. In group II, the pre and post intervention mean, SD of cervical flexion range of motion were 33.20 + 2.36 and 40.93 + 1.28 respectively. The pre and post intervention mean, SD of visual analog scale score were 6.06 + 1.10 and 2.20 + 0.67 respectively. The pre and post intervention mean, SD of neck disability index were 17.75 + 6.59 and 5.65 + 1.89 respectively. Post–intervention, the Mean difference, SD of ROM score of Group I was 39.28 + 1.65 and in Group II was 40.93 + 1.27 . After 4 weeks of intervention, the mean difference, SD of group I & group II were 6.66 + 1.23 and 7.73 + 2.37 respectively for cervical flexion range of motion. The mean difference, SD of visual analog scale were 4.13 + 0.83 and 3.86 + 0.82 respectively for group I & group II. The mean difference, SD of group I & group II were 11.25 + 3.28 and 12.10 + 4.87 respectively for neck disability index. Conclusion: This study concluded that both the thoracic mobilization and thoracic manipulation can be effectively used in the treatment of chronic mechanical neck pain to reduce the pain intensity and improve the Cervical flexion range of motion and physical disability due to neck pain among dentists .