Chronic kidney disease is progressive forms of renal disorders associated with reduced renal function having no well known etio– pathogenesis. The available treatment modalities in conventional system of medicine are still evolving but peritoneal and hemo–dialysis along with nutritional supplements and renal transplant is the final step. In this regard Ayurveda provides leads through its holistic line of management by incorporating dietary & lifestyle invention and bio– balancing effects of Ayurvedic drugs. The present case is totally treated through Ayurvedic approach and it seems to be effective and safe.