Aims and Objective: To compare mast cell density and microvessel density in different grades of oral and oropharyngeal squamous cell carcinoma in comparison to normal oral mucosa. Methods: A study was done in the Department of Pathology, MAMC Agroha. 40 consecutive cases of different grades of oral and oropharyngeal squamous cell carcinoma along with normal oral mucosa from February 2018 to March 2019 were included in the study. Biopies were fixed in 10% formalin and histopathological slides were prepared for staining with haematoxylin and eosin, toluidine blue and immunohistochemical staining using CD 34 immunomarker. Results: Micro vessel density and Mast cell density were found to be increased from normal oral mucosa to different grades of oral and oropharyngeal squamous cell carcinoma and a positive correlation was found between microvessel density and mast cell density but was not statistically significant. Conclusion: Our present study concluded a positive correlation between microvessel density and mast cell density reaching to idea that mast cells are one of the important factor for tumour progression via promotion and upregulation of angiogenesis, although the absence of statistical significance suggests the remarkable role of other angiogenic and non angiogenic factors in tumour progression.