Introduction: Unexplained or idiopathic infertility refers to failure to conceive in a couple for whom no definitive cause of infertility can be found. Usually, the duration of infertility is more than two years. One of the etiological factors for that is autoimmune response generated by various auto antibodies. Aim: To Find out the Association of Anti phospholipid Antibodies (APLA) In Cases of female Infertility Material & method: Our observational study was conducted among female patients attending OPD of Department of Obstetrics and Gynecology for the management of infertility Result: A statistically significant increase in APLA was seen in primary and secondary infertile group as compared to control group Conclusion: Autoimmunity and reproductive disturbances are associated with unexplained infertility.