Psoriasis is a most common and chronic genetic disease. There is high inflammation and proliferation of the skin. Due to this disease the skin becomes demarcated dull red, scaly plaques. It distributed particularly on the extensor prominences of the body and also in the scalp. There are several factors involved in the etiopathogenesis of psoriasis are genetic factors, metabolic factors, and immunological factors. The genetic mutations, body metabolism and the immune disorders of the body can cause elevation of adenosine deaminase (ADA), lactate dehydogenase(LDH) and uric acid levels. Psoriasis is common chronic inflammatory skin disease with a spectrum of clinical phenotype and results from interplay of genetic environments and immunological factors. Psoriasis is dynamic disease, morphological changes accompany the evolution of a newly formed lesion into an advanced plaque that can slowly enlarge or remain static.