Chronic hypophysitis is extremely rare entity & usually presents with inflammation of the pituitary gland. Most commonly presents with headaches and visual disturbances. Hypophysitis is rare & its etiology is not fully understood. It commonly affect females during pregnancy or in the postpartum period. Its clinical presentation (hypopituitarism, mass effect,hyperprolactinemia) & radiological findings may mimic pituitary adenoma. Complete laboratory evaluation with imaging is required to refine the diagnosis. The definitve diagnosis of chronic hypophysitis cannot be made without histopathology.