BACKGROUND: Diabetes mellitus (DM) and thyroid dysfunction (TD) are the two most common endocrine disorders in clinical practice . Patients with diabetes mellitus are at an increased risk of developing thyroid diseases.[1] The frequency of thyroid dysfunction in diabetic patients is higher than that of the general population and up to a third of patients with diabetes (DM) ultimately develop thyroid dysfunction. Thyroid dysfunction may impair metabolic control and add to cardiovascular disease risk in prolonged diabetic patients.[2] The objective of this study was to investigate the prevalence of Thyroid dysfunction in patients with diabetes mellitus. AIMS: Our aim is to study Pearsons correlation between thyroid dysfunction in diabetes mellitus and to examine thyroid disease screening strategies in routine diabetes care, in diabetic patients (fasting,postmeal,Random blood samples) attending clinical biochemistry OPD at tertiary care Unit, IGGMC,Nagpur. Materials & Methods – This study include about 150 patients attending the clinical Biochemistry OPD, IGGMC, Nagpur. All Diabetic patients ( more than 5 yrs) who were attending biochemistry OPD for routine Blood sugar tests were selected for this study. History was taken as per designed proforma and consent form was obtained. We collect 50 Fasting Blood samples ,50 Postmeal & 50 Random blood samples from known Diabetic patients .Collected sample was analysed for Blood sugar as well as thyroid test ie T3,T4 & TSH. Blood sugar test was run on Autoanalyser EM 460 in clinical Biochemistry Laboratory,IGGMC,Nagpur. Thyroid tests was run on Elisa reader & washer Serum values of Thyroid stimulating hormone (TSH), thyroxine (T4) and tri–iodo thyronine (T3) were assayed by ELISA tests and values were compared & correlated with Blood sugar level in Diabetics in all groups Fasting,Postmeal as well as Random Blood samples. The data was analysed & Pearsons Correlation was obtained. Student‘s T–test was used & . P value <0.05 was considered statistically significant. RESULTS: Results of our study shows Positive Pearsons correlation between TSH level & Blood sugar in Fasting, Postmeal & Random Blood samples of all Diabetic Patients while there is Negative Pearsons correlation between T3,T4 in all Diabetics. P value is found to be statistically significant in all groups (cases) CONCLUSIONS: We conclude that screening for thyroid disease among patients with diabetes mellitus should be routinely performed considering the prevalence of new cases diagnosed and the classical risk factors such as hypertension and dyslipidemia, arising from an undiagnosed thyroid dysfunction.