PURPOSE: With ever increasing load of coronary arterial disease on population of developed as well as developing countries, it has become mandatory to have a detailed knowledge about coronary arteries. Since adequate literature regarding coronary arteries and its association with coronary artery disease in people living in and around puducherry is not available, a study of coronary arteries by coronary angiogram was undertaken. AIMS AND OBJECTIVES: To study the dominance pattern of coronary arteries and its association with coronary artery disease MATERIALS AND METHODS: 200 adult coronary angiogram were studied during angiography.The origin of posterior interventricular artery was taken as the basis of dominance.coronary artery disease is considered significant if the stenosis is >70% in the luminal diameter of anterior interventricularartery,right coronary artery and circumflex artery. RESULTS: In this study, the right, left and co dominance were found to be 59%, 17.5%, and 23.5% respectively. Out of 200 subjects 112 had CAD ((56%).CAD was seen in 65.7% of patients with left dominance, 57.4% of patients with co dominance and 52.5% of patients with right dominance. The association was not statistically significant. CONCLUSION: The majority of hearts are right dominant. CAD was more common in those with left dominance there was no statistically significant association between coronary dominance and coronary artery disease.