Background: Sickle cell disease is highly prevalent in some specific castes in some districts of Central India where the growth of child is often delayed. Few data are available in this context and on the issue using the World Health Organization growth norms. Hence we conducted the present study with the aim of describing the growth of affected children aged less than 5 years. Methodology: An observational cross–sectional study was conducted from January 2019 to December 2019 for a period of 1 year, at the sickle cell centre in a tertiary care hospital in central India. The sample included 75 children with SCD aged 2 to 5 years old in steady state. Anthropometric measurements and socio–demographic data were collected and analyzed. All statistical tests were two–tailed with p<0.05 considered significant. Results: Median age of study population was 3.57 years. Low weight, height and weight for height Z–scores (<–2SD) were observed. Regression analysis indicated an association of low height–for–age and of low Body Mass Index (BMI)–for–age with age. Conclusion: This study demonstrates unexpectedly lower mean Z–score for weight, height and weight for height than reported while using WHO norms.