Granulomatous interstitial nephritis (GIN) is rare entity detected in 0.5–0.9 % of renal biopsies and a proton‑pump inhibitor‑induced GIN is infrequent. Our patient, a 80‑year‑old female (2019), on antihypertensive with normal renal function, after 30 days of rabeprazole presented with raised serum creatinine (6.5mg/dl), biopsy revealed GIN, workup for secondary causes were negative, on detailed inquiry, the patient was receiving rabeprazole for the last 1 month on the prescription of her primary physician for dyspeptic symptoms. On stopping rabeprazole, serum creatinine reduced to baseline (1 mg/dl) at 15 days, confirming the diagnosis of rabeprazole‑induced GIN.