To study efficacy of microalbumin status as an early biomarker in kidney disorder in relation and along with other biomarkers Methods–A comparative study was done in different 55 patients presented with symptoms of kidney disease at different stages. Four groups of 55 patients were studied. Group–I of diabetic patients, Group–II of Chronic Kidney Disease (CKD), Group–III of Acute Kidney injury (AKD) and Group–IV of patients under dialysis conditions. A detailed history and clinical examination were done. Result– All the selected biomarkers included in study seems to be increased from Group I to Group IV, (except calcium) and microalbumine was found to be effective early stage biomarker. Summary: blood urea and creatinine level of patients with CKD was done as routine test and Microalbumine was suggested to consider as early stage effective biomarker which can predict at hypertensive and diabetic case.