Dengue fever is a mosquito borne illness caused by Dengue virus. Liver involvement in Dengue is very common and can cause a mild to moderate rise in transaminases but can rarely cause acute fulminant heaptic failure. We present one such case of a 30 year old Hypothyroid, Diabetic and morbidly obese female from Western India who presented with typical manifestations of Dengue fever. Basic laboratory parameters were normal on admission. Initially she responded to treatment but following that she developed acute fulminant hepatic failure and renal failure to which she finally succumbed. This case reveals one of the very rare and fatal complication of Dengue infection in the form of acute fulminant hepatic failure. Other factors including race, diabetes, haemoglobinopathies, pre–existing liver damage and the use of hepatotoxic drugs may also play a role [188]