Background: Chronic kidney disease (CKD) is defined as irreversible loss of kidney function or estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2 for a period of 3 months or more. Uric acid (UA) is an end product of purine metabolism which is widely recognized as an independent risk factor of cardiovascular disease. Aims: This case control study was plan to assessed the correlation of serum Uric Acid with estimated Glomerular Filtration Rate (eGFR) in CKD patients. Methodology: In the study 50 diagnosed patients of CKD (stage 4 and 5), age between 20 to 60 years were enrolled. 50 age and sex matched healthy subjects constituted the control group. Serum Urea, Creatinine and uric acid were estimated for all the enrolled subjects. eGFR was calculated by Cockeroft and Gault formula. Results were compared between CKD patients and control group by applying suitable statistical test. Result: Mean eGFR was significantly lower in CKD group (10.28± 4.18 ml/min/1.73m2, p <0.0001) as compared to healthy subjects. Mean serum uric acid were significantly higher in CKD patients (8.02 ± 1.84 mg/dl, p <0.0001) as compared to healthy subjects. A significant negative correlation was observed between Serum uric acid and eGFR on applying Spearmanns’s correlation (r = –0.463, p <0.0001). Conclusion: High level of serum uric acid was found to be associated with significant fall in eGFR. Finding of the study suggest a strong association of hyperuricemia with progression of CKD. Therefore, uric acid can be considered as an independent risk factor for development of end stage renal disease (ESRD)