Background: Primary diseases of salivary glands have highly heterogeneous clinical and pathological features accordingly their management. Globally a lot of studies have been done, but till now there is no uniformly globally accepted study. Objective: The objective were (1) to find out incidence of primary diseases of salivary glands (2) clinical and pathological presentation of disease (3)effectiveness of various modalities of treatment and there outcome. Materials and methods: this is a prospective study of primary diseases of salivary glands in sasoon general hospital, pune Maharashtra. Datas collected from general surgery, dental and ENT departments. Results: out of total 48 cases there were 19 tumors, 20 cystic lesions, 8 sialolithiasis and 1 sialadenitis. Thesis cases were analyzed according to the parameter of age, sex, location, clinical features, radiographic findings, histopathological appearance, and medical modalities used to treat and there outcome. These were compared with the studies conducted in the other parts of the world. Conclusion: in conclusion, the data and results obtained here were similar to previously published articles and literatures in other countries and other parts of India and world. However, some differences were observed, these differences may be due to racial factors, pathology centers of sample collection and duration and timing of studies