Dentinal hypersensitivity (DH), or cervical dentinal sensitivity, is a frequent clinical disorder. It is defined as pain arising from exposed dentine typically in response to thermal, chemical, tactile or osmotic stimuli. A combination of laser therapy and topical desensitizing agents, can increase the success of the treatment compared with either treatments alone. The Aim of this study was to evaluate the Efficacy Of Er,Cr:YSGG (Erbium, Chromium: Yttrium–Scandium–Gallium–Garnet) Laser With Different Topical Desensitizing Agents In Immediate Management Of Dentinal Hypersensitivity. As per the inclusion criteria in the present study ; patient who had cervical abrasion with dentinal hypersensitivity without any other defects like decay or fracture was selected for the study. Four tooth were treated with different treatment protocols & one control tooth with no treatment. The different treatment protocols were; Group 1: Laser application only, Group 2 : Topical Fluoride activated with Laser, Group 3 : Topical GC tooth mousse activated with Laser, Group 4 : Desensitizing tooth paste activated with Laser. The assessment of the patients’ pain was done with cold air blast test (CAB) and visual analyzing scale (VAS) after stimulation using cold air & probe respectively. Patients’ pain was assessed before and just after treatment, and also 1 week and 1 month after the treatment. The results of the study indicated that combination of lasers and desensitizing agents can increase the treatment outcome of dentin hypersensitivity than when used alone.