AIM: The aim of this study was to compare the compressive resistance of PVS interocclusal record material after disinfection at different time intervals MATERIAL &METHOD: 24 specimens of the VPS interocclusal recording material(IMPRINT BITE) were prepared using a cylindrical stainless steel mould according to ADA no.19 .The manipulation of VPS was done by an auto–mixing gun, which was injected into the mould. Then specimens were divided into 4 groups according to disinfection time: Group A–control(no immersion) (n=6),Group B–immersion for 10 min (n=6), Group C–immersion for 30 min (n=6), Group D–immersion for 60 min (n=6) .The disinfectant used was 2% Gluteraldehyde .Then the specimens were stored in tightly sealed containers and kept for 24 hours. Compression resistance of the specimens were determined using a Universal Testing Machine with a compressive force of 25N for1min. The specimens were loaded to breakage or failure and value was expressed in Megapascals. RESULT: Statistical analysis was done using chi square and anova test. The mean compressive resistance of Group A is found to be 9.47±0.64, Group B 10.25±0.95, ,Group C is 10.47±0.58,Group D is 11.04±0.68 and was found to be statistically significant(0.017). CONCLUSION:.The compressive resistance of VPS (IMPRINT BITE) interocclusal record material Imprint Bite increases with increase in disinfection time