Aim of study : Comparing efficacy of gingival depigmentation by laser and scalpel technique. Method: A Randomized control split mouth study was conducted for 30 patients with gingival pigmentation. Dummet Oral Pigmentation Index (DOPI) for pigmentation and Visual Analoug Scale (VAS) for pain and wound healing index, by Tal et al 2003 for wound healing was evaluated for both segment (laser) and control sites (Scalpel technique) at baseline, after 1 week, 1month, 3months and 6 months. Results: Both the groups showed significant reduction in DOPI score i.e., 0 at baseline and after 1 week interval after treatment. DOPI score increased to 1 for 29/30 sites treated with scalpel technique. At 3 month DOPI increased to 2 for 28/30 sites treated with scalpel and increased to 1 for 29/30 sites treated with laser. DOPI are increased to 7 for 23/30 sites treated with Scalpel and sites treated by Laser increased upto 4 for 26/30 at 6 months(P=0.0601). This indicates recurrence rate for pigmentation is higher after scalpel treatment. VAS Score was significantly high for scalpel post operatively and after 1 day then laser group (P=0.038) WHI (Wound Healing Index) score when compared in both groups complete epithelisation was seen in all sites treated with Laser ( P=0.313). Conclusion: It can be concluded that Laser can be effectively and efficiently used for depigmentation by keeping patients acceptance and comfort in mind and also the long term results and ease of use when compared to scalpel technique.