The overall incidence of infertility has remained relatively unchanged over the past 3 decades however the evaluation and treatment of infertility have changed dramatically since that time. Infertility is a medical problem that affects a vast proportion of the world‘s young population (10–15%). In present study around 250 cases are taken and after excluded abnormal male factor, fallopian tube, any organic pathology and other exclusion criteria discuss above 100 cases were taken and study was conducted. Both hypothyroidism and hyperprolactinemia may result in menstrual disorders. Oligomenorrhoea was most common in infertile women. Hypothyroidism is commonly associated with hyperprolactinemia and such patients exhibit ovulatory failure. Hence, assessment of serum TSH and prolactin levels are mandatory in the work up of all infertile women, especially those presenting with menstrual irregularities. The treatment of hyperprolactinemia with dopamine agonist can normalize circulating prolactin levels. Bromocriptine is administered in 2 to 3 divided doses with a total of 2.5–40 mg/dl. The dose is slowly advanced every 4 to 10 days as tolerated until the serum prolactin is normalized and the symptoms are relieved. Cabergolin administered at 0.25–2 mg once or twice weekly is much potent and better tolerated than bromocriptin. Being infertile is a stress to the individual, family and to the society as whole. Proper diagnosis and treatment of causative factors in this condition can help them to conceive early and lead to a better social life.