From the literature review in the recent years, it is well noted that surgeons tend to avoid using prophylactic antibiotics following the surgical removal of the non infected third molars, and have started focusing on more important local factors that may play an important role in avoiding postoperative complications.1 A randomized double blind placebo controlled trial is carried out for sequential observation , data generation and analysis to determine the effect of antibiotics , upon the pain , swelling and tris–mus following the surgical removal of impacted mandibular third molars and com–pared and evaluated the response and consequences exhibited by same type of sam–ples with no antibiotics after the removal of impacted mandibular third molars in the sample of 50 patients in each group. We can conclude that prescribing antibiotics after removal of impacted mandibular third molar produces less postoperative swelling and less amount of trismus than with the non antibiotic group but the difference was not statistically significant so there is no justification for using antibiotics routinely for third molar surgery and therefore it should not be recommended but universally non administration of antibiotics cannot be practiced in vulnerable individuals