Objectives – To co–relate the histopathological diagnosis with gross examination and clinical diagnosis in cases of appendicitis Methods – A study was conducted over a period of 6 months in 39 cases of appendectomy. The study included detailed clinical history, physical examination and relevant blood and radiological investigations. Results – Out of the 39 appendectomy specimens, 20 cases were found in males and 19 in females. Most cases (35.89%) were found in the age group 21 to 30 years. The histopathological diagnosis was Acute appendicitis in 17 (43.58%) cases, Acute gangrenous – 5 cases (12.82 %), Recurrent –2 cases (5.12%) & Chronic appendicitis – 15 cases (38.46%). Summary – Confirmation of the clinical and radiological diagnosis by histopathological diagnosis is necessary in all cases of appendectomy to rule out the diagnosis other than the routine cases