Asthikshaya is degenerative changes where depletion of Asthidhatu is seen. Defining feature of Osteoporosis (Asthikshaya) is reduced bone density which causes micro architectural deterioration of bone tissue and leads to an increased risk of fracture.[1] By Ashrayashrayibhaava– Vata dosha and Asthi Dhatu is inversely proportional to each other. Vata vruddhi causes Asthikshaya.[2] So, patients were diagnosed with osteoporotic range. 80 patients were taken in study which was divided in group A (40 patients) trail group in which drug Asthishrinkhala Churna and Ashwagandha Churna and Group B Tablet Calcium Carbonate were taken. Pre and post screening of BMD and Sr. Calcium done. Observation and Statistical Analysis shows that treatment was significantly effective in the parameters of Asthi Shool , BMD, Sr. Calcium