Gunja is also known as jequirity bean or rosary pea, is an herbaceous flowering plant in the bean family Fabaceae is widely described Up–Visha drugs. In Ayurveda it is decribed as vanaspatij visha as in modern science, it is organic irritant vegetable poison. All the parts are toxic mostly seeds are more hazardous due to its irritant property. By shodhan samskara, its seeds traditionally used for the treatment of sciatica, leprosy and alopecia contains the toxic protein, abrin, a type 2 ribosome inactivating protein. The purified (detoxified) Gunja seeds exert pharmacological actions such as antimicrobial, diuretic, expectorant, purgative, emetics, aphrodisiac, hair growth stimulator and abortifacient. This article explain the ayurvedic and modern review of Gunja w.s.r. to agadtantra.