Background & Objective: Chronic Rhino Sinusitis is one of the most common otorhinolaryngologic diseases encountered in routine ENT practice. Chronic rhinosinusitis significantly impacts the quality of life by interfering with the general health, vitality and social functioning and cause decrease in productivity at school or work place. The objective of the study is to compare effect of functional endoscopic sinus surgery on the symptom profile in patients with chronic rhinosinusitis and also to confirm that FESS is the modality of treatment in patients with refractory chronic rhinosinusitis. Study Design: Prospective Clinical study. Methodology: A prospective study was done in 100 patients who had been diagnosed as cases of CRS based on TFR Criteria. The patients underwent FESS. The symptom profile of the patients were assessed preoperatively and post operatively at regular intervals for a period of 6 months and compared. Results: In this study, the total numbers of patients were 100. The mean age of patients in our study was 36.8 years (Range 10 to 70 years) with a male to female ratio of 2:1(male 66 & female 34). The most common symptom in our study was Nasal Obstruction (89 %), followed by Hyposmia/Anosmia (68%), Headache (66%), Facial Pain and Pressure (42%), Nasal Discharge/ PND (32%) and Fatigue (18%) respectively. After a follow up period of 6 months Nasal Obstruction responded best to FESS (91%), followed by PND (87.5%), Headache (84.8%) and Facial Pain (83.3%) respectively. Conclusion: On analysis of the symptom profile of patients with CRS, Nasal Obstruction, Hyposmia and Headache were the most common symptoms. The quality of life in majority of symptomatic patients with CRS significantly improved with FESS