IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-9-4-24883 Original Research Paper A Comparative clinical study of post operative analgesia with gelfoam soaked with Ropivacaine or Levobupivacaine, placed in epidural space during spine surgery. Prem Shanker Malviya Dr. Dr. Raghvendra Pratap Singh Dr. April 2020 9 4 01 02 ABSTRACT

A comparative , clinical , randomized study was undertaken to compare two local anaesthetic drugs – Levobupivacaine and Ropivacaine for postoperative analgesia during spine surgeries. A total of 90 patients were recruited who were divided into 30 each in control , Levo–bupivacaine and Ropivacaine groups. Observations for vital parameters , quality and duration of analgesia were made. Methods: Patients were randomized into three groups, group C (control) receiving 10 ml saline soaked gelfoam, group R receiving 10 ml 0.25% ropivacaine soaked gel–foam and group L receiving 10 ml 0.25% levobupivacaine soaked gelfoam. Postoperative 24 hours Heart rate (HR), Mean arterial pressure (MAP) and Visual analogue score (VAS) were rec–orded and time of 1st analgesic requirement (in hours) and total dose of analgesic requirement in the form of injection diclofenac sodium (75mg) i.v were recorded. Conclusions: Postoperative analgesia produced by two local anaesthetic drugs was significantly longer than seen in control group (p < 0.05) . Epidural application of gelfoam soaked Levobupivacaine showed better re–sponse in terms of lower pain scores and lesser rescue analgesic consumption than Ropivacaine (p < 0.05) . Hence, epidural gelfoam soaked Levobupivacaine or Ropivacaine can be effectively used for postoperative pain management in patients undergoing laminectomy , however Levobu–pivacaine stands better since it produced longer duration of analgesia. Future study – Same ex–periment can be extended in future with the help of indwelling catheter at the site of the wound and drugs being injected at the wound site as and when required.