Objective: To study the anti–depressant activities of aqueous extract of Withania coagulans fruits in Swiss albino mice using tail suspension test. Materials and Methods: Tail suspension test (TST) was used for assessing the anti–depressive activity of Withania coagulans fruits aqueous extract. If the extract had antidepressant activity, then it was expected that the period of mobility would increase and immobility would decrease. This decrease in immobility, if found statistically significant, was considered for antidepressant activity. Results: There was statistically significant (p–value < 0.001) association observed between aqueous extract of Withania coagulans fruits with depressive effect on mood in Swiss albino mice by tail suspension test. Conclusion: The aqueous extract of Withania coagulans fruits did not demonstrate antidepressant activity in Swiss albino mice. In contrast it revealed depressive effect on the mood in the Tail suspension test (TST).