Organophosphates are used mainly in the fields as pesticides and herbicides but are also used as petroleum additives, lubricants, antioxidants and plastic modifiers. Most cases of organophosphate toxicity result from exposure in an agricultural setting, not only among those mixing or spraying the pesticide or herbicide but also among workers returning prematurely to sprayed fields. Absorption may occur through the skin, by inhalation, or through the gastrointestinal tract. Organophosphates compounds inhibit the enzyme acetylcholinesterase by phosphorylation, resulting in acute cholinergic symptoms, with both central and neuromuscular manifestations. This review will focus on organophosphates induced delayed polyneuropathy, which is a relatively rare and less known manifestation of organophosphate poisoning. The review will discuss about the clinical presentation, pathogenesis, molecular mechanisms of OPIDP in man and the possibilities of treatment