Worldwide, head and neck cancer accounts for 3,30,000 deaths annually. Malignant tumors in the head and neck region are treated by surgery with chemotherapy and or radiotherapy. Radiation results in acute or late injury to surrounding normal tissue known as Osteoradionecrosis. A literature search of major databases was performed for the identification of studies on the use of adjunctive hyperbaric oxygen therapy in treatment of osteoradionecrosis of the jaws. Six publications including 158 patients were considered. This meta–analysis is consistent with the results of studies documented in literature and confirms its modest usefulness as an option in this patient population, with a disease cure–rate of about 46.35% ((CI: 22.74– 70.87) and no new adverse effects.