Background: The measurement of markers of inflammation or thrombosis has been proposed as a method to improve the prediction of risk in patients with vascular disease. Aims and Objectives: The role of C–reactive protein (CRP) as a novel plasma marker of atherothrombotic disease is currently under investigation. We related plasma CRP levels to first ischemic stroke and its role as a diagnostic aid. Methods: Eighty consecutive patients without thrombolysis with a first ischemic stroke patients were examined with the exclusion of risk factors. CT scan of brain was done after 24 hours of onset of symptoms to confirm the diagnosis. Plasma CRP level was determined before 72 hours of onset of symptoms in all CT confirmed ischemic stroke patients.CRP was randomly measured in 40 healthy individuals as a control group. Results: The CRP concentration in ischemic strokes independent of infarction site, the value was more between 41–60 years of age group and almost equal in both gender. 64 of the 80 ischemic strokes studied had CRP value >6 mg/l and only 16 patients had <6 mg/l (p<0.001), chi square test value is ²=27.88, which is statistically significant. Only 4 of the 40 control group had CRP >6 mg/l, which is insignificant. Interpretation and Conclusion: The CRP level is significantly higher in ischemic strokes and by its elevation ischemic strokes can be diagnosed positively but sub–types of cerebral infarction cannot be differentiated at the time of early diagnosis