IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-9-4-24963 Original Research Paper Comparative evaluation of ketamine-propofol and fentanyl- propofol for insertion of LMA in children Kusum Gupta Dr. Dr Ujjwal Sourav Dr. April 2020 9 4 01 02 ABSTRACT

Introduction: Inadequate depth of anaesthesia may provoke coughing, gagging and laryngospasm which may lead to adverse haemodynamic changes and increase incidence of regurgitation and aspiration. Methodology: This is a Prospective, randomized, double blinded, comparative study conducted at Department of anaesthesia, IMS ,BHU during Oct 2019 to Feb 2020.60 patients were randomly divided into 2 group , 30 each. In Group PK–ketamine 0.5mg kg–1, in Group PF–fentanyl 2ug kg–1 was given intravenously immediately before induction with propofol 2.5 mg kg–1.Results: The incidence of limb movements was less in Group Propofol +Fentanyl compared to Group Propofol+ Ketamine. Coughing or gagging was seen in 2.86% of both the groups. Resistance to insertion was showing more in Propofol + Ketamine group. The systolic blood pressure(SBP), diastolic blood pressure(DBP) and mean arterial pressure(MAP) were statistically more with Ketamine group than Fentanyl group Conclusions: co–induction with Fentanyl (2μg/kg) prior to Propofol (2.5 mg/kg) for insertion of Laryngeal Mask Airway in children provided better insertion conditions and minimal alteration in haemodynamic parameters than co–induction with Ketamine (0.5 mg/kg) and Propofol (2.5 mg/kg)