Realizing and accepting alcohol problem can cause a lot of stress, and quitting drinking will be even more stressful. This study is aimed at assessing the effect of JPMR therapy on stress among clients with alcohol dependence syndrome. Study was conducted at deaddiction centre with 60 clients (30 in control 30 in experimental group) with alcohol dependence syndrome. The screening tool (CIWA–Ar) and the data collection tool (socio demographic data sheet and structured stress rating scale) were used for the study. After the screening, pre–test was administered for both the control and experimental groups on first day, the experimental group were received JPMR therapy for 7 consecutive days. Both groups were given post–test on the 7th day after pre–test. Findings of the study showed that the JPMR therapy had an effect on the clients with alcohol dependence syndrome in deaddiction centre in reducing stress (p<0.05).