Background & Objective: Thyroid function disorders lead to changes in the lipoprotein metabolism. We conducted this study with an aim to evaluate the relationship of glycaemic status and lipid fractions in subclinical hypothyroid, overt hypothyroid and hyperthyroid patients. Methodology: The present study was conducted on 200 overt hypothyroid, subclinical hypothyroid and hyperthyroid patients attending the Medicine OPD of Raja Sukhdev Singh District Hospital Poonch. The results of patients were compared with 100 healthy control subjects of either sex of similar age group. Results: All the lipid fraction were comparable to those of studied groups and they were significantly deranged, as compared to those of Group–I. The mean serum fructosamine (FA) level was observed statistically significant (p<0.001) in Group–II and Group–III and vice versa in the Group –IV subjects. Conclusion: The fructosamine values which are mostly in excess of the fasting plasma glucose and HbA1c levels, point to a higher tendency to glycation and a reduced turnover of the proteins in the overt hypothyroid and the subclinical hypothyroid subjects, vice versa is true of the hyperthyroid subjects. This study specifies that monitoring of lipid profile in patients with thyroid dysfunction would be supportive in preventing cardiovascular diseases.