Aim: To evaluate the effect of local anaesthesia with adrenaline on Blood pressure, Heart rate and SPO2 variability during minor dental surgical procedures. Materials and Methods: A total of 50 patients were included in the study. Philips Vital monitor was placed to evaluate the parameters and changes were investigated before administering local anesthesia, during extraction procedure and post extraction. Data was tabulated and statistical analysis was done using 21 SPSS software. Results: Almost all patients had changes in the systolic blood pressure, diastolic blood pressure and pulse rate during extraction procedure. Very minimal change was observed in SPO2 levels. Conclusion: Significant changes are noted in changes in systolic blood pressure, diastolic blood pressure and pulse rate pre administration of local anesthesia, during extraction, and post extraction procedure. SPO2 has no significant differences.