Background : Cardiovascular disease is the leading cause of death worldwide . Inflamation plays an important role in the formation of atherosclerotic plaque. Hence, its assessment by various biomarkers is of paramount importance to assess the disease severity. AIM : This study was conducted to determine the extent and severity of disease process by estimating hsCRP , the biomarker of inflammation. Material & Method : This is a hospital based observational study carried out in the department of cardiology of SCB Medical college , Cuttack , Odisha from july 2018 to October 2018 & included patients of 18 years to 80years of age . hsCRP was measured in all the patients of ACS who satisfied the inclusion criteria . Result : A total of 104 patients were enrolled for the study . The mean age of presentation was 53.71 ± 9.8 yrs. Females were 13% in number. 44(42.3%) were diabetic, 36(34.62%) were hypertensive, 28(26.9%) were smokers and 34(32.7%) were found to be over weight (BMI > 23) . The mean hsCRP level was 6.66 ± 3.64 mg/L in diabetics , 6.92 ± 3.54 mg/L in smokers, 6.75 ± 3.79 mg/L in hypertensives and 6.74±3.64 mg/L in over weight patients. Conclusion : There was no significant difference in hsCRP level among patients having traditional risk factors as compared to these having no risk factor.Patients with SVD,DVD & TVD had significant rise of hsCRP level compared to LMCAD group . It is probably more related to the amount of inflammation than amount of necrosis.