The treatment of open fractures are still problematic despite many advances in the management of these fractures. Objective– To investigate the use of the gentamicin coated intramedullary tibial nail in the surgical treatment of open diaphyseal tibial fractures Place & duration of study– The study was conducted at a tertiary level post–graduate institute, INDIA. The cases were operated from March 2016 to August 2018 and were followed up for one year. Design and Methodology–In this prospective case series the implant is a titanium alloy (Ti–6Al– 7Nb) nail coated with fully resorbable amorphous poly (D,L– lactide) containing gentamycin sulphate. The present study enrolled 30 patients with fracture of the tibia and the average age of 33.9 (23–54) years and mean time from injury to surgical treatment was 9.2 hours. Results– All fractures united within 11months. None of the patients has deep or chronic osteomyelitis, where 6 patients (20%) had superficial infections which responded to the antibiotic completely. At 12 months post–operatively, 73% (22 patients) have excellent knee function as per Surgeons Assessment of Final Outcome of fractures, 20% (6 patients) have a good function, 7% (2 patients) have a fair function. Conclusions– Gentamicin–coated intramedullary nail in the surgical treatment of open fractures of the tibial shaft resulted in good functional outcomes within 12 months after surgery.