Introduction: We conducted a study comparing two endoscopic techniques for removal of vesical calculus, transurethral cystolithotripsy and Percutaneuous suprapubic lithotripsy. Materials and Methods: This study included 40 patients of bladder stone treated in our hospital from between January 2016 to December 2018 who were assigned in two groups—group 1 (transurethral removal using a nephroscope or cystoscope) and group 2 (percutaneous removal using a nephroscope). Results: Statistical significant difference was observed in operating time—group 1 (28.2 ± 8.5 mins), and group 2 (44.6 + 7.3). Statistically significant difference was also observed in the postoperative stay of the patient, which was highest for the group 2 patients. Complete clearance was achieved in all the patients. Conclusions : Suprapubic stone removal using a nephroscope is safe and efficacious method of stone removal without increasing the morbidity of the patients. It decreases the urethral manipulation time.