Background: Erythroderma also known as “exfoliative” dermatitis and “the red man syndrome” is characterised by diffuse erythema, scaling, pruritus and prolonged course affecting 90% or more of body surface area. Methods: Fifty patients of erythroderma were evaluated at Government Medical College Amritsar for a period of one year to determine the aetiology, clinical features and histological changes. Clinical and histological findings were correlated. Results: Male preponderance was present by 60%. Most of the patients were in the 2nd to 7th decade. Pruritus was present in most of the patients i.e. 35 [70%). The most common clinical diagnosis of erythroderma was pre–existing dermatosis in 39 (78%) patients out of which, Air Borne Contact Dermatitis seen in 13 (26%) patients was the commonest dermatosis leading to erythroderma. The other common pre–existing dermatosis were psoriasis seen in 10 (20%) and atopic dermatitis in 8 (16%). Two patients each of pemphigus foliaceus, scabies and seborrheic dermatitis were noted while one patient each had photodermatosis and dermatophytosis. Drugs were the second commonest cause seen in 11 (22%) patients. Out of 50 cases 36 (72%) showed a good clinico histologic correlation while rest of the cases i.e. 14 (28%) did not correlate well.