As COVID –19 is declared as pandemic emergency around the world has affected huge number of living individuals. It is now believed that its person to person transmission occurs mainly via respiratory droplets/ aerosol and direct contact. Dental set up/hospital settings invariably carry the risk of infection due to the their procedural specificity involving face–to–face communication or direct transmission (cough, sneeze, and droplet inhalation transmission) and contact transmission (contact with oral, nasal, and eye mucous membranes) Due to the high risk involved of cross contamination in the dental practitioners and patients it is important to consider this outbreak as a lethal condition of dental practice. Awareness about how to manage practice and clinics under given circumstances is of great concern. Thus, the aim of this article is to provide a brief overview of the epidemiology, sign and symptoms, and routes of transmission of this viral infection while suggesting recommendations for patient screening, infection control strategies, and patient management protocol in dental practice.