Introduction: The best technique in the management of soft tissue defects of the leg depends on some factors as the location of the defect in leg, injury extension, viability of tissues, circulatory conditions and reconstructive techniques. One of the best options for regional reconstruction of middle–third of leg is the use of muscle flaps. Another option is perforator based fascio–cutaneous flaps that is less invasive than the muscle flaps .In this study we compared both the techniques of Soft tissue coverage of leg defects. Material and methods: A total of 20 Patients meeting inclusion criteria were selected into 2 groups. Patients undergoing reconstruction of middle–third of leg defects by use of muscle flaps and fascio–cutaneous flaps. Results: In perforator based fascio–cutaneous flap coverage more time was needed. Conclusion: Perforator based fasciocutaneous flaps should be the first preference in considering the soft tissue coverage of middle–third leg defects.