Purpose: This study evaluated the efficacy of Chitosan (Axiostat) as a hemostatic in minor oral surgery. Patients and Methods: 50 patients underwent minor oral surgical procedures and haemostasis achieved with chitosan (Axiostat) and time taken for hemostasis was statistically evaluated. Results: This study involved 18 (36%) cardiac patients taking oral anticoagulants, 17 (34%) hypertensive patients and 15 (30%) diabetic patients. During minor oral surgical procedures hemostasis was achieved in mean time of 89.3 seconds with help of chitosan(Axiostat). Conclusion: The present study provides evidence that Chitosan (Axiostat) can be used as a clinically effective hemostatic dressing material that significantly shortens bleeding time following minor oral surgical procedures in medically compromised patients.