Background: It is controversial to debate on the treatment of the proximal humerus fracture; in literatures various operative modalities have been tried. There are multi–factorial difficulties in open reduction and internal fixation including osteoporotic bone, implant impingement, angular instability, loss of reduction and backing out of screws. Objectives of our study were to evaluate the results of proximal humerus anatomical plate in various groups like Neer’s type 2, 3 & 4 fractures, young and old patients. Methods: The study analyzed 15 men and 10 women aged 26 to 75 (mean, 46.64) years with Neer’s 2, 3 or 4 part proximal humerus fractures treated by anatomical locking plate. Shoulder range of movements and Functional outcomes were assessed based on the Constant and Murley scoring system. Observation & Results: In our study, 13 cases had 2 part fractures as per Neer‘s classification, while 11 cases had 3 part and 2 had four part fractures with the mean follow up of 11.8 (range 6–18) months. Out of 26 cases, 3 (11.54%) had excellent outcome, 12 (46.15%) had good outcome, 8 (30.77%) had fair outcome and 3 (10%) had poor outcome. Results were satisfactory in patients younger than 60 years, while unsatisfactory results were seen in more than 60 years of age. Conclusion: Anatomical locking plate leads to satisfactory functional outcomes in 2 & 3 part fractures but results are unsatisfactory in 4 part fractures and in older age group. This study teaches us that in fractures of proximal humerus, restoration of joint congruity is vital for restoration of joint function. Restriction of external rotation abduction suggests that greater tuberosity fragment must be anatomically reduced. Strict adherence to shoulder mobilisation protocols and compliance of patient can improve the results.