Background: Diabetes mellitus (DM) is extremely common representing a significant global health problem. Diabetes mellitus (DM) is characterized by chronic hyperglycemia and impaired carbohydrate, lipid, and protein metabolism caused by complete insufficiency of insulin secretion. Diabetes is a disease with chronic low grade inflammation. This inflammatory milieu promotes atherosclerosis and gives rise to other complications in diabetes. Aim and objective: Assessment of antioxidant enzyme in type –2 diabetes mellitus with complications, without complications and controls. Material and Methods: A total of 100 patients, 50 – Type–2 Diabetes mellitus with complications, 50 without complications for the last one year and 50 normal healthy individuals were chosen as control group. Results: The results showed a mean values of Blood Sugar levels (F), Blood Sugar levels (PP), were significantly increased (P<0.0001) in type – 2 Diabetes mellitus With complications, T2 DM. without– complications as compared to control. Another mean values of SOD, glutathione peroxidase and glutathione Reductase were highly significantly decrease (P<0.0001) in T – 2 DM with complications, T – 2 DM without complications as compared to control.