Background: Bacterial infection are among the most common dermatologic problems observed in out patient clinics. Staphylococcous aureus is the most common cause of superficial pyodermas. Contributing factors include overcrowding, hygiene, poverty, malnutrition, atopic dermatitis, and preexisting injuries. Objectives: 1. To study the association of pyoderma and atopic dermatitis 2. To see for clinical profile of cases in the out patient department 3.to check antibiotic sensitivity and resistance and to isolate the organism 4. to determine the role of predisposing factors. Materials and methods: This is a cross–sectional descriptive study conducted for the duration of 8 months( june 2019 to january 2020). Study was conducted on 150 patients of 0– 16 years who had not taken antibiotic therapy prior. From each of them two swabs were taken and labelled as A and B, swab A was from the site of lesion and swab B was from the nasal cavity. Both swabs were sent for culture and sensitivity. Results: Out of 150 patients 82 were male and 78 were females. Primary pyoderma cases were more compared to secondary. 30% had history of atopic dermatitis. Most common organism isolated from pus culture was S.aureus (46.6%) followed by in CONS( 26.6%), 18.6% of the cases showed no growth. Penicillin and amoxicillin was resistance was found in 78.5% and 65.7% for S. aureus. Culture and sensitivity from nasal swab showed S.aureus in 45.3% of cases. CONS was isolated from 26.6% of cases There was no growth in 14%. Penicillin and amoxicillin resistance was found in 54.2% and 45.2% of cases for S. aureus. Conclusion: The prevalence of pyodermas are high among children of preschool going age group. There is need health education regarding resistance to antibiotic, hygiene, spread of the disease in order to reduce transmission, resistance and several clinical manifestations.