Background: Hypertension is a global health crisis that triggers to premature death and disability of an individual (WHO, 2013). Pranayama is an aerobic practice renowned for regulating cardiac autonomic status, for maintaining normal cardio – respiratory functions (Subbalakshmi, N. K., & Saxena, S. K., 2005). Breath is a vital bridge between the body and mind (Varsha Gupta, Yogesh Singh, 2014). Slow and deep breathing keep oneself under control on the mind and helps individual to reduce the stress that will have impact on the reduction of high blood pressure (Subbalakshmi, N. K., & Saxena, S. K., 2005). The objective of present study is to evaluate the effectiveness of pranayama on hypertensive clients. The researcher adapted a pre–experimental design. After obtaining administrative permission from the selected hospital, the subjects were recruited after obtaining their consent. Purposive sampling technique were used and allotted 75 hypertensive clients in this study. Nadisodhan pranayama was used as intervention for pre–experimental group. After 21 days, post–test blood pressure was recorded in the outpatient clinic of selected hospital at Cuttack. The results were calculated through SPSS version 21. The findings show that there was a statistical significant (P ≤ 0.001) reduction in the mean scores of blood pressure among the subjects from the pre intervention to posttest.This concludes that addition of pranayama can be a useful supplementary management with antihypertensive drugs to decrease the high blood pressure.