Imaging is an essential part of endodontic practice, from diagnosis and treatment planning to outcome assessment. For decades, intraoral radiographs are widely used in the field of endodontics to detect the presence, location and size of periapical lesions. Although this imaging modality provides valuable information it has its own limitations in the form of anatomic superimposition, compression of three–dimensional (3D) structures in a two–dimensional (2D) image, geometric distortion etc. This may lead to compromised diagnostic information and outcome of the treatment. The introduction of cone beam computed tomography (CBCT) in dentistry provided us with a diagnostic tool that overcomes most of these limitation of conventional radiographic techniques. CBCT has great potential to become a valuable tool for the diagnosis and management of endodontic problems, as well as for assessing root fractures, the presence of periapical lesions, resorption, perforations, particular root canal anatomies and the nature of the alveolar bone topography around the teeth. This review aims to provide comprehensive information related to the principles of Cone beam computed tomography and its potential applications in the management of various endodontic conditions.