The therapeutic role of bacteriophage in bacterial infection has promising results. Due to the emergence of multi drug resistant bacteria, the role of bacteriophage as an adjuvant with antimicrobial therapy or use as a single antibacterial agent against different infections also has been documented. The role of bacteriophage has surpassed its therapeutic range limited to bacterial infection and now it is seen as a potential antiviral and anti –fungal agent. In COVID 19 or SARS CoV 2 infection cytokine storm medicated by Nuclear Factor–kB(NF–kB) has lead to significant mortality worldwide. Bacteriophages are potential inhibitors of this transcription mediator directed over exaggerated immune response and could serve as an agent of therapeutic importance.